Download e-book for kindle: Advanced Pharmaceutical Solids (Drugs and the Pharmaceutical by Jens T. Carstensen

By Jens T. Carstensen

ISBN-10: 0585427712

ISBN-13: 9780585427713

ISBN-10: 0824704312

ISBN-13: 9780824704315

Delivering present info on crystallization, dissolution from debris and polydisperse populations, powder volumes and densities, comminution, rainy granulation, and hard-shell tablets, complex Pharmaceutical Solids, describes moisture isotherms with crystalline solids, files the consequences of moisture on solid-state balance, highlights pill physics and ideas, explains sustained liberate by means of microencapsulation, provides prediction equations for solubility in binary solvents, discusses particle sizes and diameters, identifies Brunauer, Emmett, and Teller Isotherms and extra! contemplating houses of solids, permeamitry and fuel absorption equipment, amorphates, and purification via pH-change precipitation, complex Pharmaceutical Solids is a necessary reference for pharmacists pharmaceutical scientists medicinal, actual, floor, colloid, and analytical chemists and biochemists and an efficient textual content for upper-level undergraduate and graduate scholars in those disciplines.

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Extra resources for Advanced Pharmaceutical Solids (Drugs and the Pharmaceutical Sciences)

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L rie T, Uekama K (1997). J Pharm Sci 86:147. , Carst€nsen JT (1975). Ann Pharm Fr 33:433. i A, Hanaee J (1997). Int J Pharm 154:245. i A, Acree WE (1998). Int J P h a m l67:177. k (1996). J P h a m Sci 87:193. Joz~iakowskiMJ, Nguyen NT, Sisco JJ, ~ p a ~ k c aCW (1972). J P h a m Sci 61:281. M, ~uyot-Hermann A-M, Guyot J-C (1998). Int J P h a m 17051. Galan YCR (1987). Cienc Ind Farm 6:325. ir H (1998). Int J P h a m 163:115. Loftsson T, Brewster ME (1996). J Pharm Sci 85: 1017. Lordi N, Sciarrone , Ambrosio T, Parta AN (1964).

The development of this concept in the following is based on the Schottky defect, but it would also apply to vacancies of other natures. Suppose (Fig. 3), that a crystal contains nine molecules. There is but one wayof arranging them. If one of the internal molecules is moved to the surface, there will be { lo1}= 10 ways of doing c E3 A D A nucleus or crystal (A) grows on the surface, and two sites are shown. ” Schottky Frenkel Vacancy Frenkel, Schottky, and screw defects. 0 000 0 0 000 9 Posit’ions One Way 10 Positions 10 Ways 11 Posltlons 55 ways Situation where one and two Schottky defects are created in a crystal with (originally) nine lattice sites.

8. 9. 10. 11. 12. 13. 14. 15. ffect of Surfactants 46 46 46 47 Solubility of c o ~ ~ o u nisd of s great importance in pharmaceutics, and the subject has been subdivide^ into the foregoing subtopics. henever the tern solubility is employed, it is tacitly assumed that it is equilibrium solubility. In other words, it assumes that a (stable) solid (the solute) is laced in contact with a li~uid (thes o l ~ eand ~ ~the ~ system , is all owe^ to be agitate^ for a long while, or by other ~ e a n allowed s to reach a state of e ~ u i l i b r i ucharacteri~ed ~, by the fact t ~ a the t co~cent~ation of solute has reached a co~stantlevel.

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Advanced Pharmaceutical Solids (Drugs and the Pharmaceutical Sciences) by Jens T. Carstensen

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